Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions
Xiang Liu, Dan Song, Zemin Zhang, Jiatong Lin, Canzhan Zhuang, Haiying Zhan, Hua Cao
Abstract
An efficient and straightforward metal-free regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis.
Topics & Concepts
RegioselectivityDisulfide bondChemistryMetalCombinatorial chemistryOrganic chemistryCatalysisBiochemistrySynthesis and Reactivity of HeterocyclesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions