Rhodium(<scp>iii</scp>)-catalyzed carboxylate-directed <i>ortho</i>-selective thiolation of benzoic acids
Dongjie Wang, Kehan Zhou, Jingyu Zhang, Yingsheng Zhao
Abstract
A rhodium-catalyzed carboxylate-directed thiolation reaction has been developed for constructing C–S bonds on benzoic acids, and the key precursor of roflumilast can be furnished <italic>via</italic> this reaction.
Topics & Concepts
ChemistryRhodiumCarboxylateCatalysisBenzoic acidMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions