Aggregation of water soluble octaanionic phthalocyanines and their photoinactivation antimicrobial effect in vitro
Д. Б. Березин, В. В. Макаров, Serafima Znoyko, Vladimir E. Mayzlish, А. В. Кустов
Abstract
Aggregation of sulfophenylsulfanyl-substituted phthalocyanine and its aluminum complex has been investigated in aqueous solutions of DMF or nonionic surfactant Tween 80 by UV-VIS spectroscopy and DLS. Aluminum complex is less aggregated and 4.5 orders of magnitude stronger bound to the micelles of Tween 80 compared to a metal-free ligand. Under irradiation the phthalocyanine derivatives reveal a pronounced antimicrobial activity towards both Gram(+) and Gram(−) archive microflora in vitro.
Topics & Concepts
ChemistryPhthalocyanineAntimicrobialAqueous solutionMicellePulmonary surfactantIn vitroMetalLigand (biochemistry)PhotochemistryNuclear chemistryOrganic chemistryBiochemistryReceptorPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics