Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation

Mingyu Li, Ashfaq Ur Rehman, Yaqin Liu, Kai Chen, Shaoyong Lu

2021Advances in protein chemistry and structural biology31 citationsDOI

Topics & Concepts

Allosteric regulationKinaseHyperphosphorylationPhosphorylationFunction (biology)Drug discoveryCell biologyChemistryBiochemistryBiologyEnzymeProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerBiochemical and Molecular Research