Lower Urinary Tract Symptoms in US Women: Contemporary Prevalence Estimates from the RISE FOR HEALTH Study
Siobhan Sutcliffe, Chloe Falke, Cynthia S. Fok, James W. Griffith, Bernard L. Harlow, Kimberly Kenton, Cora E. Lewis, Lisa Kane Low, Jerry L. Lowder, Emily S. Lukacz, Alayne D. Markland, Gerald McGwin, Melanie Meister, Elizabeth R. Mueller, Diane K. Newman, Ratna Pakpahan, Leslie Rickey, Todd Rockwood, Melissa A. Simon, Abigail R. Smith, Kyle Rudser, Ariana L. Smith, Linda Brubaker, Elizabeth R. Mueller, Marian Acevedo‐Alvarez, Colleen M. Fitzgerald, Cecilia T. Hardacker, Jeni Hebert‐Beirne, James W. Griffith, Kimberly Kenton, Melissa A. Simon, Oluwateniola Brown, Julia Geynisman‐Tan, Margaret G. Mueller, Alayne D. Markland, Camille P. Vaughan, Tamera Coyne‐Beasley, Kathryn L. Burgio, Cora E. Lewis, Gerald McGwin, Beverly Rosa Williams, Emily S. Lukacz, D. Yvette LaCoursiere, Sheila Gahagan, Jesse Nodora, Lisa Kane Low, Miller Jm, Abby Smith, Gerald McGwin, Kyle Rudser, Sonya S. Brady, Cynthia S. Fok, Bernard L. Harlow, Peter Scal, Todd Rockwood, Diane K. Newman, Ariana L. Smith, Amanda Berry, Andrea Bilger, Terri H. Lipman, Heather Klusaritz, Ann E. Stapleton, Jean F. Wyman, Siobhan Sutcliffe, Aimee S. James, Jerry L. Lowder, Melanie Meister, Leslie Rickey, Deepa R. Camenga, Shayna D. Cunningham, Linda Brubaker, Jenna M. Norton
Abstract
PURPOSE: We aimed to estimate the prevalence of a wide range of lower urinary tract symptoms (LUTS) in US women, and explore associations with bother and discussion with health care providers, friends, and family. MATERIALS AND METHODS: We analyzed baseline data collected from May 2022 to December 2023 in the RISE FOR HEALTH study-a large, regionally representative cohort study of adult female community members. LUTS and related bother were measured by the 10-item Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index, and discussion was assessed by a study-specific item. RESULTS: Of the 3000 eligible participants, 73% (95% CI 71%-74%) reported any storage symptoms, 52% (95% CI 50%-53%) any voiding or emptying symptoms, and 11% (95% CI 10%-13%) any pain with bladder filling, for an overall LUTS prevalence of 79% (95% CI 78%-81%). This prevalence estimate included 43% (95% CI 41%-45%) of participants with mild to moderate symptoms and 37% (95% CI 35%-38%) with moderate to severe symptoms. Over one-third of participants reported LUTS-related bother (38%, 95% CI 36%-39%) and discussion (38%, 95% CI 36%-40%), whereas only 7.1% (95% CI 6.2%-8.1%) reported treatment. Urgency and incontinence (including urgency and stress incontinence) were associated with the greatest likelihood of bother and/or discussion (adjusted prevalence ratios = 1.3-2.3), even at mild to moderate levels. They were also the most commonly treated LUTS. CONCLUSIONS: LUTS, particularly storage LUTS such as urgency and incontinence, were common and bothersome in the RISE study population, yet often untreated. Given this large burden, both prevention and treatment-related interventions are warranted to reduce the high prevalence and bother of LUTS.