Litcius/Paper detail

Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation

Haixia Liu, Xinyu Ding, Linyi Liu, Qianglong Mi, Quanju Zhao, Yubao Shao, Chaowei Ren, Jinju Chen, Ying Kong, Xing Qiu, Nicola Elvassore, Xiaobao Yang, Qianqian Yin, Biao Jiang

2021European Journal of Medicinal Chemistry56 citationsDOI

Topics & Concepts

CereblonUbiquitin ligaseChemistryCancer researchDasatinibChronic myelogenous leukemiaMdm2K562 cellsUbiquitinLeukemiaPharmacologyMyeloid leukemiaIn vitroBiochemistryBiologyImatinibImmunologyApoptosisGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways