Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation
Haixia Liu, Xinyu Ding, Linyi Liu, Qianglong Mi, Quanju Zhao, Yubao Shao, Chaowei Ren, Jinju Chen, Ying Kong, Xing Qiu, Nicola Elvassore, Xiaobao Yang, Qianqian Yin, Biao Jiang
Topics & Concepts
CereblonUbiquitin ligaseChemistryCancer researchDasatinibChronic myelogenous leukemiaMdm2K562 cellsUbiquitinLeukemiaPharmacologyMyeloid leukemiaIn vitroBiochemistryBiologyImatinibImmunologyApoptosisGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways