Dietary berberine supplementation improves growth performance and alleviates gut injury in weaned piglets by modulating ileal microbiota and metabolites
Cui Zhu, Meifang Le, Zhentao He, Yinshan Bai, Jun Yang, Jinling Ye, Zhuang Chen, Zongyong Jiang
Abstract
< 0.05). The ileal metabolome analysis showed that the metabolic pathways including primary and secondary bile acid biosynthesis and bile secretion were significantly enriched by BBR treatment. Collectively, dietary BBR supplementation effectively improved the growth performance and alleviated the diarrhea and intestinal injury induced by ETEC K88 in weaned piglets, which might closely involve the modulation of ileal microbiota and metabolites.
Topics & Concepts
BerberineGut floraIleumChemistryBiologyPharmacologyBiochemistryBerberine and alkaloids researchPhytochemistry and biological activities of Ficus speciesAlkaloids: synthesis and pharmacology