DDX5 inhibits type I IFN production by promoting degradation of TBK1 and disrupting formation of TBK1 − TRAF3 complex
Yanwei Zhang, Jing Cen, Gaoliang Yuan, Zhao Jia, Kangyong Chen, Wa Gao, Jing Chen, Mikołaj Adamek, Zhiying Jia, Jun Zou
Topics & Concepts
IRF3TANK-binding kinase 1Cell biologyBiologyRIG-IIRF7Innate immune systemInterferonVirologyAutophagyViral replicationHelicaseRNA Helicase AVirusImmune systemSignal transductionGeneticsApoptosisGeneRNAProtein kinase CMitogen-activated protein kinase kinaseinterferon and immune responsesViral Infections and VectorsRNA regulation and disease