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First Follow-Up of Cardiac Amyloidosis Treated by Tafamidis, Evaluated by Absolute Quantification in Bone Scintigraphy

Dimitri Bellèvre, Alban Bailliez, Sylvestre Maréchaux, Alain Manrique, Frédéric Mouquet

2021JACC Case Reports17 citationsDOIOpen Access PDF

Abstract

Assessment of absolute myocardial hydroxydimethylene diphosphonate–technetium-99m uptake using standardized uptake value with a single-photon emission computed tomography–computed tomography cadmium zinc telluride camera (Discovery NM/CT 670CZT, GE Healthcare, Chicago, Illinois) in a patient with cardiac transthyretin-related amyloidosis treated with tafamidis showed a decrease in hydroxydimethylene diphosphonate cardiac uptake. This imaging technique should be helpful in monitoring therapy and evaluating prognosis. (Level of Difficulty: Intermediate.)

Topics & Concepts

Cardiac amyloidosisMedicineNuclear medicineBone scintigraphyScintigraphyCadmium zinc tellurideRadiologyRadionuclide imagingTransthyretinInternal medicineEngineeringElectrical engineeringDetectorAmyloidosis: Diagnosis, Treatment, OutcomesMedical Imaging and Pathology StudiesSarcoidosis and Beryllium Toxicity Research
First Follow-Up of Cardiac Amyloidosis Treated by Tafamidis, Evaluated by Absolute Quantification in Bone Scintigraphy | Litcius