New Mechanistic Insights into Purine Biosynthesis with Second Messenger c-di-AMP in Relation to Biofilm-Related Persistent Methicillin-Resistant Staphylococcus aureus Infections
Liang Li, Yi Li, Fengli Zhu, Ambrose L. Cheung, Genzhu Wang, Guangchun Bai, Richard A. Proctor, Michael R. Yeaman, Arnold S. Bayer, Yan Q. Xiong
Abstract
antibiotic treatment. Given the high morbidity and mortality associated with the persistent infection, there is an urgent need to understand the specific mechanism(s) of this syndrome. In the current study, we demonstrate that a functional intersection between purine biosynthesis and the second messenger c-di-AMP plays an important role in VAN persistence in experimental MRSA endocarditis. Targeting this pathway may represent a potentially novel and effective strategy for treating these life-threatening infections.
Topics & Concepts
Staphylococcus aureusPurineMicrobiologyMutantBiofilmBiosynthesisBiologyPurine metabolismStaphylococcal infectionsEnzymeGeneCyclaseVancomycinSecond messenger systemBiochemistryExtracellularNucleotide salvageSignal transductionAntibioticsChemistryMethicillin-resistant Staphylococcus aureusMultidrug toleranceBiochemical and Molecular ResearchInfective Endocarditis Diagnosis and ManagementBacterial biofilms and quorum sensing