A G-Protein-Coupled Receptor Modulates Gametogenesis via PKG-Mediated Signaling Cascade in Plasmodium berghei
Pengpeng Wang, Xuefeng Jiang, Liying Zhu, Dan Zhou, Mingyang Hong, Lu He, Lumeng Chen, Shijie Yao, Yan Zhao, Guang Chen, Chengqi Wang, Liwang Cui, Yaming Cao, Xiaotong Zhu
Abstract
Environmental changes from humans to mosquitoes activate gametogenesis of the malaria parasite, an obligative process for parasite transmission, but how the signals are relayed remains poorly understood. Here, we show the identification of a Plasmodium G-protein-coupled receptor, GPR180, and the characterization of its function in gametogenesis.
Topics & Concepts
GametogenesisPlasmodium bergheiBiologyPlasmodium (life cycle)Parasite hostingMalariaCell biologyReceptorGametocyteSignal transductionFunction (biology)GeneticsPlasmodium falciparumImmunologyGeneEmbryogenesisComputer scienceWorld Wide WebMalaria Research and ControlNeurobiology and Insect Physiology ResearchComplement system in diseases