Chiari network and patent foramen ovale associated with stroke

Abstract

Central MessageThe Chiari network might promote patent foramen ovale foramen and result in stroke. Successful removal might be possible through a minimally invasive open-heart approach.See Commentary on page 48. The Chiari network might promote patent foramen ovale foramen and result in stroke. Successful removal might be possible through a minimally invasive open-heart approach. See Commentary on page 48. The Chiari network is a mesh-like fenestrated embryonic remnant that is found in the right atrium at the junction of the superior and inferior vena cavae. Although this finding is generally benign, it has been shown to favor the retention of a patent foramen ovale (PFO) and promote thrombotic and embolic complications.1Schneider B. Hofmann T. Justen M.H. Meinertz T. Chiari's network: normal anatomic variant or risk factor for arterial embolic events?.J Am Coll Cardiol. 1995; 26: 203-210Crossref PubMed Scopus (181) Google Scholar We present a 46-year-old man with previous history of cardioembolic stroke who was found to have Chiari network, concomitant PFO, and associated mitral valve mass. He underwent surgical excision through a minimally invasive open-heart surgery via mini right thoracotomy, and his postoperative course was uncomplicated. Northwestern University institutional review board reviewed the study (STU00214992) in May 2021, and determined the project was not research and no institutional review board approval is required. Institutional consent for use of de-identified information was obtained. A 46-year-old man suffered a right occipital stroke with persistent hemianopsia. Transesophageal echocardiogram showed a 3.5-cm mass in the right atrium, suggestive of an atypical Chiari network, a PFO, and a 1.3-cm mitral valve mass consistent with a Lambl excrescence. There was trivial mitral regurgitation. Because the patient's Risk of Paradoxical Embolism score suggested a 72% chance that the stroke was due to PFO, this prompted the decision to pursue closure. Furthermore, because Lambl excrescence and PFO are both known causes of stroke and the patient's clinical history did not indicate which could be the more likely cause, open-heart surgery for mitral valve mass resection, right atrial mass resection, and PFO closure was determined to be the optimal treatment for eliminating the likely causes of recurrent stroke (Video 1). The decision to pursue surgery over medical management or device closure of PFO was made by a multidisciplinary heart team consisting of cardiologists and cardiovascular surgeons. There was no attempt at anticoagulation before surgery, and antiplatelet therapy was halted 1 week before the operation. After induction of anesthesia and establishment of arterial and venous access, the right chest wall was entered through the fourth intercostal space lateral to the right nipple. A trocar was placed at the sixth interspace for liver retraction and insufflation of CO2. Cardiopulmonary bypass was initiated with good venous drainage using femoral and superior vena cava cannulas. The pericardium was opened horizontally away from the phrenic nerve, and antegrade cold blood hyperkalemic cardioplegia was used. Left atriotomy was made, and an atrial lift retractor was placed through a stab incision through the fourth intercostal space just lateral to the sternal edge. The mitral valve was inspected and no mass was found, confirming findings on the intraoperative transesophageal echocardiogram. The PFO was then closed with 2 rows of running 4-0 polypropylene suture from the left atrial side. There was no associated septal aneurysm. The left atrium was closed with a single row of running 3-0 polypropylene suture and the heart was deaired through the anastomotic line. Cross-clamp was then removed and the heart regained sinus rhythm spontaneously. A vertical right atriotomy was made in the lower third of the right atrium, and a large fenestrated membrane measuring 6 cm was resected from the area of the inferior vena cava (Figure 1). This structure was consistent with Chiari network (Figure 2). Another row of running 4-0 polypropylene suture was placed at the PFO on the right atrial side, and right atriotomy was closed with 2 rows of running 4-0 polypropylene suture. The patient was then weaned from bypass and decannulated. The patient's postoperative recovery was uncomplicated.Figure 2Postoperative image after resection of Chiari network measuring 6 cm in length.View Large Image Figure ViewerDownload Hi-res image Download (PPT) The Chiari network is the remnant of the embryologic right valve of sinus venosus, which normally regresses to form the crista terminalis and the eustachian and thebesian valves. Failure of regression leads to a web-like structure as shown in Figure 1. Although often an incidental finding, the Chiari network been shown to be associated with PFO and atrial septal aneurysm. The proposed mechanism for this phenomenon is that the Chiari network results in an embryonic right atrial flow pattern, which directs blood toward the interatrial septum, leading to an increased likelihood of aneurysm or PFO development.1Schneider B. Hofmann T. Justen M.H. Meinertz T. Chiari's network: normal anatomic variant or risk factor for arterial embolic events?.J Am Coll Cardiol. 1995; 26: 203-210Crossref PubMed Scopus (181) Google Scholar Furthermore, the Chiari network has also been posited as a source of thrombi and emboli.2Orbison J.L. Thrombosis of anomalous chordae in the right atrium (Chiari's network).Am Heart J. 1949; 37: 119-122Crossref PubMed Scopus (6) Google Scholar,3Edwards P. Wozniak M. Corretti M. Price T.R. Cardiac Chiari network as an etiology for embolic stroke.J Stroke Cerebrovasc Dis. 1994; 4: 238-241Abstract Full Text PDF PubMed Scopus (6) Google Scholar Therefore, the combined presence of PFO with Chiari network suggests an individual's risk of developing cerebrovascular accident or transient ischemic attack is increased. This has been described in other reports in which the Chiari network has been associated with cerebrovascular complications.4Schwimmer-Okike N. Niebuhr J. Schramek G.G. Frantz S. Kielstein H. The presence of a large Chiari network in a patient with atrial fibrillation and stroke.Case Rep Cardiol. 2016; 2016: 4839315PubMed Google Scholar In our patient, the Risk of Paradoxical Embolism score suggested a strong likelihood that stroke was due to PFO, and provides further supporting evidence for Chiari network as a potential source of embolism. Furthermore, the Chiari network has also been associated with other complications such as valvular dysfunction, endocarditis, arrhythmia, and catheter-trapping.5Islam A.K.M.M. Sayami L.A. Zaman S. Chiari network: a case report and brief overview.J Saudi Heart Assoc. 2013; 25: 225-229Crossref PubMed Scopus (15) Google Scholar From these examples, it appears that although Chiari network is largely uncomplicated, it might not be as clinically benign as previously thought. In this report, we describe a successful resection of Chiari network and simultaneous repair of PFO via minimally invasive cardiac surgery using mini right thoracotomy. Resection of the Chiari network should include the attachments to the os of the coronary sinus and the right atrial wall, while avoiding injury to the interatrial septum. We believe this is the first published instance of Chiari network removal using this approach. Our report suggests that surgical removal of the Chiari network is possible using a minimally invasive cardiac approach. In addition, because the Chiari network might be associated with a wide variety of harmful consequences, including stroke and transient ischemic attack, surgical resection might prove to be a viable and justifiable option for management of this unique phenomenon. eyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI1NDNkYTM5NWIzZDljYjNiM2I4MDU2Y2I5ZmYxYWVjYyIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjk1MDE2MjcxfQ.pKtRWNLNITyzlocId72W4l8yCvSd-Nfp4mUserivCc8bOUsRVGh26UoFv9uz1rSaphZKxKlMrl2tEwjoTQPAHjXd3mAeYoQMxD4v5QOToZeYbm6OPTm2mUe0UpBZszPeYsDTjjyqsPjNcUvXPNMvVaYS9F1SLvFrvyMNSXWVTQDE7LNKsTPdr6iivj1ZdMZTg9WOOYA0wpkoGOG6UtztbB-HsN7Xs-8vPjPrYKxLDJudsl1TnNOkRhUgl-DQzekMIEKpDLrD6QH_9-LxWE5ueFoCphdHDVEXohcoo6qSR8GLBw2dC6m1-LSDr6FM17nRKObCcNiBRTNso0cgi77bBA Download .mp4 (35.1 MB) Help with .mp4 files Video 1Chiari network and patent foramen ovale case study. A narrated case study with surgical video is presented. Video available at: https://www.jtcvs.org/article/S2666-2507(21)00762-8/fulltext. Download .jpg (.2 MB) Help with files Video 1Chiari network and patent foramen ovale case study. A narrated case study with surgical video is presented. Video available at: https://www.jtcvs.org/article/S2666-2507(21)00762-8/fulltext. Commentary: Your eyes can deceive you; don't trust themJTCVS TechniquesVol. 11PreviewThe Chiari network, found infrequently in the right atrium, is a fenestrated, net-like embryonic remnant from failure of resorption of the right-sided sinus venosus valve. Developmentally, the right valve of the sinus venosus evolves into 2 valves: the valve of the inferior vena cava (Eustachian valve) and the valve of the coronary sinus (Thebesian valve).2 Hans Chiari, an Austrian pathologist, first described this phenomenon in 13 human right atria in 1897,1 and the prevalence has been reported to be 2% to 14%. Full-Text PDF Open Access

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