Current status and trends of antimicrobial resistance among clinical isolates in China: a retrospective study of CHINET from 2018 to 2022
Weiwei Yang, Li Ding, Renru Han, Dandan Yin, Shi Wu, Yang Yang, Demei Zhu, Yan Guo, Fupin Hu, on behalf of the China Antimicrobial Surveillance Network (CHINET) Study Group, Yingchun Xu, Xiaojiang Zhang, Zhaoxia Zhang, Ping Ji, Mei Kang, Chao He, Chuanqing Wang, Pan Fu, Yuanhong Xu, Ying Huang, Zhongju Chen, Ziyong Sun, Yuxing Ni, Jingyong Sun, Yunzhuo Chu, Sufei Tian, Zhidong Hu, Jin Li, Yunsong Yu, Jie Lin, Bin Shan, Yan Du, Sufang Guo, Yanyan Wang, Lianhua Wei, Xin Wang, Hong Zhang, Chun Wang, Yunjian Hu, Xiaoman Ai, Chao Zhuo, Danhong Su, Ruizhong Wang, Hua Fang, Bixia Yu, Ping Gong, Miao Song, Dawen Guo, Jinying Zhao, Wen’en Liu, Yanming Li, Yan Jin, Yueling Wang, Kaizhen Weng, Yirong Zhang, Xuesong Xu, Chao Yan, Xiangning Huang, Hua Yu, Yi Li, Shanmei Wang, Lixia Zhang, Juan Ma, Shuping Zhou, Jiangwei Ke, Lei Zhu, Jinhua Meng, Han Shen, Wanqing Zhou, Gang Li, Wei Jia, Jinsong Wu, Yuemei Lu, Jihong Li, Jiangshan Liu, Longfeng Liao, Hongqin Gu, Lin Jiang, Wen He, Shunhong Xue, Jiao Feng, Rui Dou, Chunlei Yue, Ruyi Guo, Yan Jin, Xiaobo Ma, Yanping Zheng, Fangfang Hu, Yunsheng Chen, Qing H. Meng, Yun Xia, Shan Sun
Abstract
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Antimicrobial Surveillance Network (CHINET) was established in 2005 to monitor antimicrobial resistance in the country. This study analyzed the CHINET data from teaching hospitals and evaluated the trends of AMR in China from 2018 to 2022. A range of 163,636 to 301,917 isolates was obtained per year, with the majority being Gram-negative bacilli (69.0% to 71.8%). The proportion of important multidrug-resistant pathogens remained stable over the years. While the analysis showed diverse AMR profiles for different bacterial species. Over the five years, generally decreased resistance rates were observed from the majority of the tested species. For example, resistance to ceftriaxone decreased in Escherichia coli and Klebsiella pneumoniae , while resistance to imipenem and meropenem decreased in Pseudomonas aeruginosa . Moreover, resistance to methicillin, gentamicin, fosfomycin, and clindamycin also decreased in clinical Staphylococcus aureus isolates. On the other hand, resistance levels of Acinetobacter baumannii remained stable. Our study provides a comprehensive overview of the AMR profiles of common bacterial species in China and highlights the ongoing efforts to address this challenge.