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Long non-coding RNA GAS5 contributes to the progression of nonalcoholic fatty liver disease by targeting the microRNA-29a-3p/NOTCH2 axis

Juanjuan Cui, Yang Wang, Haowei Xue

2022Bioengineered34 citationsDOIOpen Access PDF

Abstract

Alanine aminotransferase: ALT; Aspartate aminotransferase: AST; Enzyme linked immunosorbent assay: ELISA; Hepatocellular carcinoma: HCC; High-fat diet: HFD; Long non-coding RNA: Lnc RNA; Long non-coding RNA GAS5: GAS5; MicroRNAs: MiRNAs; Nonalcoholic fatty liver disease: NAFLD; Quantitative reverse transcription PCRs: RT-qPCRs; siRNA negative control: si-NC; Total cholesterol: TC; Triglyceride: TG.

Topics & Concepts

Nonalcoholic fatty liver diseaseGAS5Gene knockdownSteatosisBiologyTriglycerideLong non-coding RNACancer researchmicroRNAFatty liverInternal medicineEndocrinologyDownregulation and upregulationCholesterolMedicineDiseaseGeneBiochemistryCancer-related molecular mechanisms researchLipid metabolism and disordersCircular RNAs in diseases
Long non-coding RNA GAS5 contributes to the progression of nonalcoholic fatty liver disease by targeting the microRNA-29a-3p/NOTCH2 axis | Litcius