Neuronal-driven glioma growth requires Gαi1 and Gαi3
Yin Wang, Yuan-Yuan Liu, Min‐Bin Chen, Kai-Wen Cheng, Lina Qi, Zhi-qing Zhang, Ya Peng, Ke-ran Li, Fang Liu, Gang Chen, Cong Cao
Abstract
Neuroligin-3 (NLGN3) is necessary and sufficient to promote glioma cell growth. The recruitment of Gi1/3 to the ligand-activated receptor tyrosine kinases (RTKs) is essential for mediating oncogenic signaling.
Topics & Concepts
GliomaNeuroliginEctopic expressionCancer researchGene silencingCell biologySmall hairpin RNACell growthProtein kinase BMAPK/ERK pathwayBiologyDownregulation and upregulationSignal transductionCell migrationChemistryCellGene knockdownReceptorCell cultureBiochemistryExcitatory postsynaptic potentialGeneticsGeneNeuroblastoma Research and TreatmentsGlioma Diagnosis and TreatmentTGF-β signaling in diseases