CaMKII holoenzyme mechanisms that govern the LTP versus LTD decision
Sarah G. Cook, Olivia R. Buonarati, Steven J. Coultrap, K. Ulrich Bayer
Abstract
stimulation and autonomous activity and (ii) a trans-subunit reaction enabled complete activity shutdown and feed-forward inhibition of further T286 phosphorylation. These are fundamental additions to the long-studied CaMKII regulation and function in neuronal plasticity.
Topics & Concepts
Long-term potentiationNeuroscienceComputer scienceBusinessBiologyChemistryBiochemistryReceptorNeuroscience and Neuropharmacology ResearchMitochondrial Function and PathologyAmino Acid Enzymes and Metabolism