Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
Taylor Morrisette, Katherine L. Lev, Razieh Kebriaei, Jacinda C. Abdul‐Mutakabbir, Kyle Stamper, Sandra Morales, Susan M. Lehman, Gregory S. Canfield, Breck A. Duerkop, César A. Arias, Michael J. Rybak
Abstract
Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium . After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments.
Topics & Concepts
Enterococcus faeciumDaptomycinLytic cycleBacteriophageMicrobiologyBiologyAntibioticsEnterococcusVirologyPhage therapyAntibiotic resistanceBacteriaVirusStaphylococcus aureusVancomycinEscherichia coliGeneticsGeneBacteriophages and microbial interactionsAntimicrobial Resistance in StaphylococcusMicrobial infections and disease research