Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents

Abstract

Background: Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it a candidate for structural modification. Thus, this study incorporated the triazole moiety on thymol and the chlorination of thymol moiety to help improve its biological potency. Materials and methods: NCTC 13438 and Meropenem Resistant Results: at a concentration of 100 μg/ml. Conclusion: These results provide additional evidence of the exploitation of natural products like thymol as leads for drug development against medically important bacterial pathogens.

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