Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α
Yang Zhou, Yingjun Quan, Yusheng Chen, Yijun Huang, Renhong Huang, Weiping Yu, Dejun Wu, Min Ye, Zhijun Min, Bo Yu
Abstract
Colorectal cancer (CRC) is an important digestive tract tumor with high malignancy. Nearly one million people suffer from CRC every year with a mortality rate of 33%. Therefore, it is urgent to determine the mechanism for the development of CRC, in order to find more effective diagnosis markers and therapeutic targets.
Topics & Concepts
Gene knockdownWarburg effectN6-MethyladenosineMethyltransferaseColorectal cancerCancer researchRNAChemistryBiologyMolecular biologyMethylationCancerGeneticsBiochemistryCancer cellGeneRNA modifications and cancerCancer-related molecular mechanisms researchRNA regulation and disease