Efficient healing of diabetic wounds by MSC-EV-7A composite hydrogel <i>via</i> suppression of inflammation and enhancement of angiogenesis
Xinyi Long, Qian Yuan, Rui Tian, Wanting Zhang, Lang Liu, Minghui Yang, Xin Yuan, Zhujie Deng, Quanjiang Li, Ronghui Sun, Yuyi Kang, Y. Y. Peng, Xiubin Kuang, Lingfang Zeng, Zhengqiang Yuan
Abstract
study revealed that the combination therapy consisting of EVs and 7A in an alginate hydrogel was more efficient for the healing of diabetic wounds in rats than monotherapy using either EV or 7A hydrogels. The underlying mechanisms include suppression of inflammation, improvement of skin cell proliferation and migration, and enhanced collagen fiber disposition and angiogenesis in wounds. In summary, the MSC-EV-7A hydrogel potentially constitutes a novel therapy for efficient healing of chronic diabetic wounds.
Topics & Concepts
AngiogenesisInflammationMesenchymal stem cellWound healingChemistryExtracellular vesiclesSelf-healing hydrogelsCell biologyCellCancer researchImmunologyMedicineBiochemistryBiologyPolymer chemistryWound Healing and TreatmentsExtracellular vesicles in diseaseMesenchymal stem cell research