Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
Marko Rudar, Jane Naberhuis, Agus Suryawan, Hanh V. Nguyen, Barbara J. Stoll, Candace C. Style, Mariatu A. Verla, Oluyinka O. Olutoye, Douglas G. Burrin, Marta L. Fiorotto, Teresa A. Davis
Abstract
Extrauterine growth restriction often occurs in premature infants but may be mitigated by optimizing enteral feeding strategies. We show that intermittent bolus feeding does not increase skeletal muscle protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in preterm pigs. This attenuated anabolic response of muscle to intermittent bolus feeding, compared with previous observations in pigs born at term, may contribute to deficits in lean mass that many premature infants exhibit into adulthood.
Topics & Concepts
AnabolismBolus (digestion)Animal scienceLean body massParenteral nutritionInternal medicineEndocrinologyBiologyMedicineChemistryBody weightInfant Nutrition and HealthClinical Nutrition and GastroenterologyMuscle metabolism and nutrition