Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods
Artis Klapars, John Y. L. Chung, John Limanto, Ralph Calabria, Louis‐Charles Campeau, Kevin R. Campos, Wenyong Chen, Stephen M. Dalby, Tyler A. Davis, Daniel A. DiRocco, Alan M. Hyde, Amude M. Kassim, Mona Utne Larsen, Guiquan Liu, Peter E. Maligres, Aaron Moment, Feng Peng, Rebecca T. Ruck, Michael Shevlin, Bryon Simmons, Zhiguo J. Song, Lushi Tan, Timothy J. Wright, Susan L. Zultanski
Abstract
/TMDSO; (4) dynamic stereoselective phosphoramidation using a chiral nucleophilic catalyst. The new route improves the yield of uprifosbuvir 50-fold over the previous manufacturing process and expands the tool set available for synthesis of antiviral nucleotides.
Topics & Concepts
Combinatorial chemistryComputer scienceChemistryComputational biologyNanotechnologyBiologyMaterials scienceHIV/AIDS drug development and treatmentBiochemical and Molecular ResearchHepatitis C virus research