Research progress in protein microarrays: Focussing on cancer research
Guang Chen, Lina Yang, Guoxiang Liu, Yunfan Zhu, Fanghao Yang, Xiaolei Dong, Fenghua Xu, Feng Zhu, Can Cao, Di Zhong, Shuang Li, Huhu Zhang, Bing Li
Abstract
Although several effective treatment modalities have been developed for cancers, the morbidity and mortality associated with cancer continues to increase every year. As one of the most exciting emerging technologies, protein microarrays represent a powerful tool in the field of cancer research because of their advantages such as high throughput, small sample usage, more flexibility, high sensitivity and direct readout of results. In this review, we focus on the research progress in four types of protein microarrays (proteome microarray, antibody microarray, lectin microarray and reversed protein array) with emphasis on their application in cancer research. Finally, we discuss the current challenges faced by protein microarrays and directions for future developments. We firmly believe that this novel systems biology research tool holds immense potential in cancer research and will become an irreplaceable tool in this field.