An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of <i>P. aeruginosa</i>
Katja Koeppen, Thomas H. Hampton, Roxanna Barnaby, Carolyn Roche, Scott A. Gerber, Young Ah Goo, Byoung-Kyu Cho, Danielle M. Vermilyea, Deborah A. Hogan, Bruce A. Stanton
2023American Journal of Physiology-Lung Cellular and Molecular Physiology17 citationsDOIOpen Access PDF
Abstract
Human RNA fragments transported in extracellular vesicles interfere with Pseudomonas aeruginosa drug efflux pumps. A combination of rRNA fragments and ciprofloxacin packaged in nanoparticles or EVs may benefit patients with antibiotic-resistant P. aeruginosa infections.
Topics & Concepts
Pseudomonas aeruginosaEffluxCiprofloxacinMicrobiologyExtracellularAntibioticsOfloxacinVesicleChemistryRNAExtracellular vesiclesRibosomal RNABacteriaBiologyCell biologyBiochemistryGeneMembraneGeneticsBacterial Infections and VaccinesExtracellular vesicles in diseasePneumonia and Respiratory Infections