Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
Milo Gatti, Giulio Virgili, Pier Giorgio Cojutti, Paolo Gaibani, Matteo Conti, Carmelo Sturiale, Federico Pea, Pierluigi Viale
Abstract
We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful.
Topics & Concepts
VentriculitisCeftazidime/avibactamMedicineAvibactamPharmacodynamicsCarbapenemIntensive care medicineCeftazidimePharmacologyInternal medicineMicrobiologyAntibioticsCerebrospinal fluidBiologyPseudomonas aeruginosaPharmacokineticsBacteriaGeneticsAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in BacteriaBacterial Infections and Vaccines