New Tools to Probe the Protein Surface: Ultrasmall Gold Nanoparticles Carry Amino Acid Binders
Selina Beatrice van der Meer, Inesa Hadrović, Annika Meiners, Kateryna Loza, Marc Heggen, Shirley K. Knauer, Peter Bayer, Thomas Schräder, Christine Beuck, Matthias Epple
Abstract
of 8 ± 1 μM, as shown by ITC. We conclude that ultrasmall nanoparticles can act as versatile carriers for artificial protein ligands and strengthen their interaction with the complementary patches on the protein surface.
Topics & Concepts
Isothermal titration calorimetryNanoparticleChemistryColloidal goldNuclear magnetic resonance spectroscopyConjugated systemCombinatorial chemistryCrystallographyStereochemistryNanotechnologyMaterials scienceOrganic chemistryPolymerBiochemistryBiochemical and Structural CharacterizationRNA and protein synthesis mechanismsProtein Structure and Dynamics