Iodine‐Mediated Regioselective Radical Cyclization of <i>o</i>‐Vinylaryl Isocyanides with Disulfides/Diselenides Leading to 2‐Chalcogenated Quinolines
Yanan Li, Fan Chen, Xing‐Guo Zhang, Hai‐Yong Tu
Abstract
Abstract An iodine‐mediated radical cyclization of o ‐vinylaryl isocyanides with disulfides or diselenides was developed. The atom‐economic reaction provides a method for regioselective construction of the 2‐chalcogenated quinolines in 42–93% yields by incorporation of both chalcogen atoms of disulfides or diselenides into quinolines.
Topics & Concepts
ChemistryRegioselectivityChalcogenIodineCombinatorial chemistryMedicinal chemistryRadical cyclizationOrganic chemistryCatalysisSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions