Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics
Nicole D. Wagner, Hejun Liu, Henry W. Rohrs, Gaya K. Amarasinghe, Michael L. Gross, Daisy W. Leung
Abstract
binding, these β-sheet and adjacent residues show significant protection. Collectively, our findings suggest that NiV V binding disrupts the helicase fold and dynamics of MDA5 to antagonize host antiviral immunity.
Topics & Concepts
MDA5VirologyHendra VirusBiologyVirusEncephalitisRNAGeneticsGeneRNA interferenceVirology and Viral Diseasesinterferon and immune responsesViral Infections and Vectors