CD8<sup>+</sup> tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis
Xiao Feng, Fan Yu, Xin‐Liang He, Peipei Cheng, Qian Niu, Liqin Zhao, Qian Li, Xiao-Lin Cui, Zi-Heng Jia, Shu-Yi Ye, Limei Liang, Linjie Song, Liang Xiong, Fei Xiang, Xiaorong Wang, Wan-Li Ma, Hong Ye
Abstract
The role of CD8 + T RM cells in the development of pulmonary fibrosis was validated and studied in the classic model of pulmonary fibrosis. It was proposed for the first time that CCL18 has a chemotactic effect on CD8 + T RM cells, thereby exacerbating pulmonary fibrosis.
Topics & Concepts
BleomycinPulmonary fibrosisCD8Cytotoxic T cellFibrosisAdoptive cell transferLungT cellIdiopathic pulmonary fibrosisMedicineImmunologyPathologyCancer researchChemistryImmune systemInternal medicineChemotherapyBiochemistryIn vitroInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisCancer Immunotherapy and BiomarkersAntifungal resistance and susceptibility