The CEBPB<sup>+</sup> glioblastoma subcluster specifically drives the formation of M2 tumor-associated macrophages to promote malignancy growth
Yongchang Yang, Xingyu Jin, Yang Xie, Chunlan Ning, Yiding Ai, Haotian Wei, Xing Xu, Xianglian Ge, Tailong Yi, Qiang Huang, Xuejun Yang, Tao Jiang, Xiaoguang Wang, Yingzhe Piao, Xun Jin
Abstract
Our findings not only deepen our understanding of the formation of M2 TAMs, particularly highlighting the differential roles played by heterogeneous cells within GBM in this process, but also provided new insights for effectively controlling the malignant progression of GBM.
Topics & Concepts
GliomaCancer researchBiologyTumor microenvironmentProtein kinase BGlioblastomaTumor progressionCellSignal transductionCell biologyTumor cellsCancerGeneticsGlioma Diagnosis and TreatmentImmune cells in cancerEpigenetics and DNA Methylation