Structural and Microvascular Changes in the Macular Are Associated With Severity of White Matter Lesions
Chenlei Peng, William Robert Kwapong, Shasha Xu, Farah Mohamed Muse, Jueyan Yan, Man Qu, Yungang Cao, Hanpei Miao, Zhenxiang Zhen, Bo Wu, Zhao Han
Abstract
Microvascular impairment and neuro-axonal damage are associated with the disease cascade in WMH. We have shown that RPC and DCP densities are significantly affected, and these impairments are associated with the severity of the disease and cognitive function. OCT-A could be a useful tool in quantifying the retinal capillary densities in WMH.
Topics & Concepts
White matterMedicineHyperintensityPathologyOphthalmologyNeuroscienceMagnetic resonance imagingPsychologyRadiologyAcute Ischemic Stroke ManagementCerebral Venous Sinus ThrombosisNeurological Disease Mechanisms and Treatments