The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia
Garth T. Whiteside, Donald J. Kyle, Ram P. Kapil, Alessandra Cipriano, Ellie He, Mingyan Zhou, Manjunath S. Shet, Michele Hummel, Terri Knappenberger, Kazuya Fukumura, Yoshiyuki Matsuo, Masahiro Uehira, Shuichi Hiroyama, Nozomi Takai, S.K. Willsie, Stephen Harris
Abstract
The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.
Topics & Concepts
Nociceptin receptorNOPPartial agonistAgonistInsomniaSleep (system call)ReceptorMedicineEndocrinologyPharmacologyInternal medicinePsychologyOpioid peptideOpioidComputer scienceOperating systemNeuropeptides and Animal PhysiologyRegulation of Appetite and ObesitySleep and Wakefulness Research