Characterization of <i>pfmdr1</i> , <i>pfcrt</i> , <i>pfK13</i> , <i>pfubp1</i> , and <i>pfap2mu</i> in Travelers Returning from Africa with Plasmodium falciparum Infections Reported in China from 2014 to 2018
Jun Feng, Dongmei Xu, Xiangli Kong, Kangming Lin, He Yan, Xinyu Feng, Hong Tu, Zhigui Xia
Abstract
The artemisinin-based combination therapies (ACTs) used to treat Plasmodium falciparum in Africa are threatened by the emergence of parasites in Asia that carry variants of the Kelch 13 (K13) locus with delayed clearance in response to ACTs. Single nucleotide polymorphisms (SNPs) in other molecular markers, such as ap2mu and ubp1 , were associated with artemisinin resistance in rodent malaria and clinical failure in African malaria patients.
Topics & Concepts
ArtemisininPlasmodium falciparumBiologyNonsynonymous substitutionGenotypeGeneticsMalariaAlleleSingle-nucleotide polymorphismLocus (genetics)VirologyGeneImmunologyGenomeMalaria Research and ControlComputational Drug Discovery MethodsTrypanosoma species research and implications