Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunity against Malaria in both India and Ghana
Asier Garcia-Senosiain, Ikhlaq Hussain Kana, Susheel Kumar Singh, Bishwanath Kumar Chourasia, Manoja Kumar Das, Daniel Dodoo, Subhash Singh, Bright Adu, Michael Theisen
Abstract
< 0.001), respectively. IgG1 and/or IgG3 subclasses against five antigens from these subsets were associated with protection. Through this comparative study, maintaining uniformity of reagents and methodology, we demonstrate that NAI across diverse geographic regions may result from antibodies to multiple antigenic targets that constitute the peripheral merozoite surface protein complexes.
Topics & Concepts
Malaria vaccineAntigenMalariaBiologyMerozoite surface proteinPlasmodium falciparumAntibodyImmunityImmunologyVirologyImmune systemMalaria Research and ControlMosquito-borne diseases and controlvaccines and immunoinformatics approaches