Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function
Ye-Jin Park, Sungkyung Kim, Hyeon‐Pyo Shim, Jae H. Park, Gyunghee Lee, Tae-Yeop Kim, Min-Cue Jo, Ah‐Young Kwon, Mihwa Lee, Seong-Jae Lee, Jiwon Yeo, Hyung-Lok Chung, Hugo J. Bellen, Seung‐Hae Kwon, Sang‐Hak Jeon
Abstract
in glia is essential for the development and maintenance of brain function. We propose a mechanism that underlies these neurodegenerative phenotypes triggered by defective PS metabolism.
Topics & Concepts
PhosphatidylserineFunction (biology)Cell biologyChemistryNeuroscienceBrain functionATP synthaseBiochemistryBiologyPhospholipidEnzymeMembranePhagocytosis and Immune RegulationAutophagy in Disease and TherapyPancreatic function and diabetes