Asymmetric synthesis of 7-membered-ring-bridged 3,4-fused tricyclic indoles <i>via</i> Friedel–Crafts alkylation/annulation
Bai-Yu Xue, Chen-Ying Hou, Xiaobing Wang, Ming‐Sheng Xie, Hai‐Ming Guo
Abstract
Regio- and enantioselective Friedel–Crafts alkylation/ N -hemiacetalization and dehydration sequence were reported using Ni( ii )-PyBPI complex as catalyst, affording chiral 7-membered-ring-bridged 3,4-fused tricyclic indoles in good results.
Topics & Concepts
ChemistryTricyclicFriedel–Crafts reactionAlkylationEnantioselective synthesisAnnulationRing (chemistry)StereochemistryCatalysisOrganic chemistryAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis