Site-selective olefinic C–H cyanation <i>via</i> alkenyl sulfonium salts
Juan Ma, Jie Lin, Zilong Huang, Ping Wu, Yong‐Gui Zhou, Zhengkun Yu
Abstract
A chemo- and regioselective olefinic C–H cyanation strategy was developed via alkenyl sulfonium salts with CuCN, affording alkenyl nitriles by a site-selective interrupted Pummerer activation/palladium-catalyzed olefinic C(sp 2 )–S cyanation sequence.
Topics & Concepts
CyanationSulfoniumChemistryRegioselectivityPalladiumMedicinal chemistryOrganic chemistryCatalysisSalt (chemistry)Sulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions