A genetically encoded ratiometric indicator for tryptophan
Rongkun Tao, Kui Wang, Tian-lun Chen, Xinxin Zhang, Jian-bin Cao, Wenquan Zhao, Jiulin Du, Yu Mu
Abstract
L-tryptophan is the rarest essential amino acid found in food and cellular uptake of tryptophan is vital for protein synthesis in vertebrate animals 1 . Tryptophan metabolism is emerging as a critical hub for metabolic regulation of immune responses and neural activities through the kynurenine and serotonin pathways 1 , 2 . Metabolic reprogramming of tryptophan dynamics is highly associated with inflammation 3 , which plays important roles in neurological and cardiovascular diseases, ageing, and cancers 1 , 2 , 4 , 5 .
Topics & Concepts
TryptophanComputational biologyChemistryGeneticsBiologyAmino acidTryptophan and brain disordersGenetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation