Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer
Xiuyan Wan, Jiaqi Yin, Qianqian Yan, Hui Hu, Teng Zheng, Yuying Chai, Wei Pan, Yanan Gao, Na Li, Bo Tang
Abstract
A well-designed three-dimensional (3D) covalent organic framework (COF) was constructed as a nanocapsule for the encapsulation of horseradish peroxidase (HRP), which could realize sustained release of HRP to prolong the duration of the therapeutic agents and promote long-term enzyme prodrug therapy.
Topics & Concepts
ProdrugHorseradish peroxidaseChemistryCancer therapyEnzymeCovalent bondPharmacologyCombinatorial chemistryBiochemistryOrganic chemistryCancerMedicineInternal medicineCovalent Organic Framework ApplicationsCarbon and Quantum Dots ApplicationsAdvanced Nanomaterials in Catalysis