A direct-to-biology high-throughput chemistry approach to reactive fragment screening
Ross P. Thomas, Rachel E. Heap, Francesca Zappacosta, Emma K. Grant, Péter Pogány, Stephen Besley, David J. Fallon, Michael M. Hann, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Abstract
binding pocket. A powerful advantage of the D2B-HTC screening platform is the ability to rapidly perform iterative design-make-test cycles, accelerating the development and optimisation of chemical tools and medicinal chemistry starting points with little investment of resource.
Topics & Concepts
High-throughput screeningChemical biologyChemical libraryCombinatorial chemistryThroughputChemistryIdentification (biology)Drug discoveryCovalent bondComputer scienceNanotechnologyFragment (logic)Computational biologyBiochemistrySmall moleculeBiologyMaterials scienceOrganic chemistryAlgorithmTelecommunicationsBotanyWirelessCRISPR and Genetic EngineeringClick Chemistry and ApplicationsChemical Synthesis and Analysis