Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion
Chen Zhu, Karen O. Dixon, Kathleen Newcomer, Guangxiang Gu, Sheng Xiao, Sarah Zaghouani, Markus A. Schramm, Chao Wang, Huiyuan Zhang, Kouichiro Goto, Elena Christian, Manu Rangachari, Orit Rosenblatt-Rosen, Hitoshi Okada, Tak W. Mak, Meromit Singer, Aviv Regev, Vijay K. Kuchroo
Abstract
T cells revealed up-regulation of dysfunction-associated genes, concomitant with down-regulation of genes associated with T cell effector function, suggesting that absence of Bat3 can trigger T cell dysfunction even under highly proinflammatory autoimmune conditions.
Topics & Concepts
Signal transducing adaptor proteinTerminal (telecommunication)BiologyCell biologyComputational biologySignal transductionComputer scienceTelecommunicationsGalectins and Cancer BiologyCancer Mechanisms and TherapySignaling Pathways in Disease