Sex differences in the time course and mechanisms of vascular and cardiac aging in mice: role of the smooth muscle cell mineralocorticoid receptor
Jennifer J. DuPont, Seung Kyum Kim, Rachel M. Kenney, Iris Z. Jaffe
Abstract
These data demonstrate that the delayed and steeper decline in cardiovascular function observed in aging females can be modeled in aging mice. Moreover, the mechanisms driving vascular and cardiac aging phenotypes are distinct between males and females. Mineralocorticoid receptors in smooth muscle cells play a significant role in cardiovascular aging in both sexes; however, they do so by distinct mechanisms. Overall, these findings suggest that sex-specific therapies may be necessary to retard the aging process and improve cardiovascular disease outcomes in the aging population.
Topics & Concepts
Mineralocorticoid receptorEndocrinologyInternal medicineMineralocorticoidReceptorVascular smooth muscleCardiac muscleBiologyCardiac hypertrophyMedicineMuscle hypertrophySmooth muscleHormonal Regulation and HypertensionStress Responses and CortisolVitamin D Research Studies