Ruthenium-nitrosyl complexes as NO-releasing molecules, potential anticancer drugs, and photoswitches based on linkage isomerism
I.N. Stepanenko, Michal Zalibera, Dominik Schaniel, Joshua Telser, Vladimir B. Arion
Abstract
-NO), which can be detected spectroscopically and analyzed computationally. The investigation of photoisomerization processes in the solid state may be useful for potential application of such complexes for data storage, photochromic or photomagnetic materials or even non-linear optics. Herein we describe the major developments in the synthesis of ruthenium nitrosyl complexes, their photoinduced linkage isomerization (PLI) processes, their NO release both in the solid state and in solution, and their application as potential anticancer drugs. Illustrative examples of such innovations made mainly in the last decade are provided.
Topics & Concepts
RutheniumChemistryLinkage (software)Combinatorial chemistryLinkage isomerismStereochemistryMoleculeSmall moleculeBiochemistryMetalOrganic chemistryCatalysisGeneMolecular Sensors and Ion DetectionNitric Oxide and Endothelin EffectsSynthesis and Catalytic Reactions