The intersection of aging and estrogen in osteoarthritis
Aysegul Atasoy‐Zeybek, Kelly K. Showel, Christopher V. Nagelli, Jennifer J. Westendorf, Christopher H. Evans
Abstract
Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation, inflammation, and pain. While multiple factors contribute to OA development, age and sex are primary risk factors, particularly affecting postmenopausal women. The dramatic increase in OA risk after menopause suggests estrogen deficiency accelerates disease progression. This review explores the molecular mechanisms connecting aging and estrogen deficiency in OA development, focusing on key genes and pathways identified through RNA sequencing.
Topics & Concepts
Intersection (aeronautics)OsteoarthritisEstrogenMedicineInternal medicineGeographyCartographyPathologyAlternative medicineOsteoarthritis Treatment and MechanismsEstrogen and related hormone effectsCytokine Signaling Pathways and Interactions