Antifungal Susceptibility Profiles and Drug Resistance Mechanisms of Clinical Lomentospora prolificans Isolates
Yongqin Wu, Nina T. Grossman, Marissa Totten, Warda Memon, Anna Fitzgerald, Chunmei Ying, Sean X. Zhang
Abstract
Lomentospora prolificans is an opportunistic fungal pathogen with low susceptibility to current antifungal drugs. Here, we tested the in vitro susceptibility of 8 drugs against 42 clinical L. prolificans isolates. All isolates showed high MICs to voriconazole (MIC 90 >16 μg/ml), itraconazole (MIC 90 >16 μg/ml), posaconazole (MIC 90 >16 μg/ml), isavuconazole (MIC 90 >16 μg/ml), amphotericin B (MIC 90 >16 μg/ml), and terbinafine (MIC 90 >64 μg/ml) and high minimum effective concentrations (MECs) to micafungin (MEC 90 >8 μg/ml), with the exception of miltefosine showing an MIC 90 value of 4 μg/ml.
Topics & Concepts
PosaconazoleMicafunginTerbinafineVoriconazoleItraconazoleMicrobiologyAmphotericin BMinimum inhibitory concentrationBiologyDrug resistanceAntibioticsMedicineAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesPlant Pathogens and Fungal Diseases