Polypeptide‐ and Protein‐Based Conjugate Nanoparticles via Aqueous Ring‐Opening Polymerization‐Induced Self‐Assembly (ROPISA)
Hannah Beauseroy, Chloé Grazon, Ségolène Antoine, Mostafa Badreldin, Pedro Salas‐Ambrosio, Simon Harrisson, Élisabeth Garanger, Sébastien Lecommandoux, Colin Bonduelle
Abstract
Protein-polymer conjugates and polymeric nanomaterials hold great promise in many applications including biomaterials, medicine, or nanoelectronics. In this work, the first polymerization-induced self-assembly (PISA) approach performed in aqueous medium enabling protein-polymer conjugates and nanoparticles entirely composed of amino acids is presented by using ring-opening polymerization (ROP). It is indeed shown that aqueous ring-opening polymerization-induced self-assembly (ROPISA) can be used with protein or peptidic macroinitiators without prior chemical modification and afford the simple preparation of nanomaterials with protein-like property, for example, to implement biomimetic thermoresponsivity in drug delivery.