NaH-mediated direct C–H arylation in the presence of 1,10-phenanthroline
Kanako Nozawa‐Kumada, Yuki Iwakawa, So Onuma, Masanori Shigeno, Yoshinori Kondo
Abstract
Transition-metal-free coupling of haloarenes with unactivated arenes has been developed in the presence of NaH and 1,10-phenanthroline. Various haloarenes bearing methyl, methoxy, halogen (fluoride, chloride, and bromide), cyano, trifluoromethyl, ester, and amide groups can be cross-coupled with unactivated arenes, or heteroarenes in this reaction.
Topics & Concepts
PhenanthrolineChemistryCombinatorial chemistryTransition metalPolymer chemistryMedicinal chemistryCatalysisOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions