Discovery of novel thiazole derivatives containing pyrazole scaffold as PPAR-γ Agonists, α-Glucosidase, α-Amylase and COX-2 inhibitors; Design, synthesis and in silico study
Wael A. A. Fadaly, Ahmed Elshewy, Mohamed T. M. Nemr, Kareem Abdou, Ahmed M. Sayed, Nesma M. Kahk
Topics & Concepts
ChemistryIn silicoPyrazoleScaffoldThiazoleCombinatorial chemistryBiochemistryEnzymeStereochemistryComputational biologyBiologyBiomedical engineeringMedicineGenePeroxisome Proliferator-Activated ReceptorsClick Chemistry and ApplicationsSynthesis and biological activity