The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione
Mana Murae, Yoshimi Shimizu, Yuichiro Yamamoto, Asuka Kobayashi, Masumi Houri, Tetsuya Inoue, Takuya Irie, Ryutaro Gemba, Y. Kondo, Yoshio Nakano, Satoru Miyazaki, Daisuke Yamada, Akiyoshi Saitoh, Isao Ishii, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Masayoshi Fukasawa, Kohji Noguchi
Topics & Concepts
CysteineGlutathioneViral entryLipid bilayer fusionCell fusionReceptorBiochemistryMutantChemistryBiologyCoronavirusFusion proteinMolecular biologyCell biologyCellVirologyVirusViral replicationEnzymeRecombinant DNACoronavirus disease 2019 (COVID-19)GeneDiseaseInfectious disease (medical specialty)PathologyMedicineSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesPhagocytosis and Immune Regulation