L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Janne Tampio, Magdalena Markowicz-Piasecka, Ahmed B. Montaser, Jaana Rysä, Anu Kauppinen, Kristiina M. Huttunen
Abstract
production in the pancreas, highlighting its antioxidative efficacy. Additionally, the LAT1-utilizing derivatives were found to be hemocompatible in human plasma and endothelial cells. Since antioxidative derivative 1 was substantially delivered into the pancreas along the previously studied brain, the derivative can be considered as a safe dual-targeting drug candidate in both the pancreas and the brain.
Topics & Concepts
Oxidative stressPharmacologyChemistryAntioxidantDrug deliveryPharmacokineticsFerulic acidPancreasLipid peroxidationBiochemistryMedicineOrganic chemistryAmino Acid Enzymes and MetabolismDrug Transport and Resistance MechanismsNeuroscience and Neuropharmacology Research